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“It is like riding a bike.” This phrase refers to memory retention of a learned task in the absence of practice. Our everyday experience shows that the nervous system forms long-term motor memories. However, experimental demonstration of how motor memories are formed and retained remains elusive.
Spinal circuits are at the heart of sensorimotor transformation to generate movements. Yet, it is challenging to disentangle how spinal circuits might contribute to motor skill acquisition and retention due to the physical continuum of the brain that also participates in those processes. As such, we know little about the identities of spinal neurons or circuits that underlie the bottom-up mechanisms of motor skill learning and retention. Our recent work suggests the exciting possibility that specific cell types and circuits drive mechanisms regulating spinal learning and memory recall. We aim to understand circuit organization principles and functions that underlie motor adaptation and retention mediated by spinal circuits.
We are interested in understanding how sensory feedback regulates motor planning, learning, and execution. In this context, the lab focuses on dissecting how somatosensory, proprioceptive, and visual feedback is disseminated once the primary afferents enter the nervous system and are integrated to alter repetitive and complex motor behavior at the different hierarchical levels of the central nervous system.
We use a wide variety of methods, including detailed motor kinematic assessments, mouse genetics, viral tracing and manipulation, in vitro and in vivo electrophysiological recordings in awake behaving animals, and imaging techniques. This combinatorial approach allows us to study and alter functions of specific neuronal populations, which in turn helps us to understand their roles in sensory information processing necessary for motor output and plasticity.
Lavaud S, Bichara C, D’Andola M, Yeh S, Takeoka A. Two
inhibitory neuronal classes govern acquisition and recall of
spinal sensorimotor adaptation. Science 384,194-201.
Bertels H, Vicente-Ortiz G, El Kanbi K, Takeoka A.
Neurotransmitter phenotype switching by spinal excitatory
interneurons regulates locomotor recovery after spinal cord
injury. Nature Neuroscience 25 (5) 617–629.
Takeoka A. Proprioception: Bottom-up directive for motor
recovery after spinal cord injury. Neurosci Res 154, 1-8.
Invited review.
Takeoka A, Arber S. Functional local proprioceptive feedback
circuits initiate and sustain locomotor recovery after spinal
cord injury. Cell Reports 27 (1): 71–85.e3.
Ruder L, Takeoka A, Arber S. Long-distance descending spinal
neurons ensure quadrupedal locomotor stability. Neuron 92 (5):
1063-1078.
Basaldella E, Takeoka A, Sigrist M, Arber S. Multisensory
signaling shapes vestibulo-motor circuit specificity. Cell 163
(2): 301-12.
Takeoka A, Vollenweider I, Courtine G, Arber S. Muscle spindle
feedback directs locomotor recovery and circuit reorganization
after spinal cord injury. Cell 159 (7): 1626-1639.
Preview article in the same issue
Takeoka A, Jindrich DL, Muñoz-Quiles C, Zhong H, van den Brand
R, Pham DL, Ziegler MD, Ramon-Cueto A, Roy RR, Edgerton VR,
Phelps PE. Axon regeneration can facilitate or suppress hindlimb
function after Olfactory Ensheathing Glia transplantation. J.
Neurosci 31: 4298-4310.
Kolb J, Tsata V, John N, Kim K, Möckel C, Rosso G, Kurbel V,
Parmar A, Sharma G, Karandasheva K, Abuhattum S, Lyraki O, Beck
T, Müller P, Schlüßler R, Frischknecht R, Wehner A, Krombholz N,
Steigenberger B, Beis D, Takeoka A, Blümcke I, Möllmert S, Singh
K, Guck J, Kobow K, Wehner D. Small leucine-rich proteoglycans
inhibit CNS regeneration by modifying the structural and
mechanical properties of the lesion environment. Nat Commun 14,
6814.
Rehman R, Miller M, Krishnamurthy S, Kjell J, Elsayed L, Hauck
S, Heuvel F, Conquest A, Chandrasekar A, Ludolph A, Boeckers T,
Mulaw M, Goetz M, Morganti-Kossmann M, Takeoka A, Roselli F.
Met/HGFR triggers detrimental reactive microglia in TBI. Cell
Reports 41, 111867.
Ceyssens F, Carmona MB, Kil D, Deprez M, Tooten E, Nuttin B,
Takeoka A, Balschun D, Kraft M, Puers R. Chronic neural
recording with probes of subcellular cross-section using 0.06
mm² dissolving microneedles as insertion device. Sensors and
Actuators B: Chemical 284: 369-376.
Ziegler MD, Hsu D, Takeoka A,¬ Zhong H, Ramon-Cueto A, Phelps
PE, Roy RR, Edgerton VR. Further evidence of Olfactory
Ensheathing Glia facilitating axonal regeneration after a
complete spinal cord transection. Exp Neurol 229: 109-119.
Takeoka A, Kubasak MD, Zhong H, Kaplan JA, Roy RR, Phelps PE.
Noradrenergic innervation of the rat spinal cord caudal to a
complete spinal cord transection: Effects of olfactory
ensheathing glia. Exp Neurol, 222, 59-69.
Takeoka A, Kubasak MD, Zhong H, Roy RR, Phelps PE. Serotonergic
innervation of the caudal spinal stump in rats after complete
spinal transection: effect of olfactory ensheathing glia. J Comp
Neurol, 515, 664-76.
Kubasak MD, Jindrich DL, Zhong H, Takeoka A, McFarland KC,
Muñoz-Quiles C, Roy RR, Edgerton VR, Ramón-Cueto A, Phelps PE.
OEG implantation and step training enhance hindlimb-stepping
ability in adult spinal transected rats. Brain, 131, 264-76.
Laboratory for Motor Circuit Plasticity
RIKEN Center for Brain Science
Room 101b, CBS Neural Circuit Genetics Research Building
2-1 Hirosawa, Wako-shi,
Saitama 351-0198, Japan
Aya Takeoka - Team Leader
aya.takeoka (at) riken.jp
Yuko Goto - Administrative Assistant
yuko.goto (at) riken.jp
+81-48-462-1111 ext. 6252 (from abroad)
048-462-1111 ext. 6252 (from Japan)
For directions to RIKEN please refer to this page.